Identifying Nitric OxideSOLVING A SCIENTIFIC MYSTERY Dr. Ignarro recognized the benefit of nitroglycerin for vascular function. But how did it work? Perhaps it was Nitric Oxide that caused the vessels to relax. It was a fascinating theory, and Dr. Ignarro set out to test it. Sure enough, his research proved that nitroglycerin acts by releasing Nitric Oxide, causing blood vessels to relax and widen, which in turn resulted in greater blood flow and oxygen to the heart, decreased chest pains and a decline in blood-pressure levels.
DISCOVERING THE SOURCE OF NITRIC OXIDE Dr. Ignarro then theorized that if the body responded to an outside chemical, perhaps it already existed in the body. Although there were plenty of naysayers, Dr. Ignarro decided to test whether the body could make its own Nitric Oxide, which led to more research, which eventually led to the Nobel Prize.
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